Protein function prediction via protein-protein interaction - a Support Vector Machine approach

Master'sMASTER OF SCIENC

Effects of training datasets on both the extreme learning machine and support vector machine for target audience identification on twitter

The ability to identify or predict a target audience from the increasingly crowded social space will provide a company some competitive advantage over other companies. In this paper, we analyze various training datasets, which include Twitter contents of an account owner and its list of followers, using features generated in different ways for two machine learning approaches - the Extreme Learning Machine (ELM) and Support Vector Machine (SVM). Various configurations of the ELM and SVM have been evaluated. The results indicate that training datasets using features generated from the owner tweets achieve the best performance, relative to other feature sets. This finding is important and may aid researchers in developing a classifier that is capable of identifying a specific group of target audience members. This will assist the account owner to spend resources more effectively, by sending offers to the right audience, and hence maximize marketing efficiency and improve the return on investment

Using support vector machine ensembles for target audience classification on Twitter

The vast amount and diversity of the content shared on social media can pose a challenge for any business wanting to use it to identify potential customers. In this paper, our aim is to investigate the use of both unsupervised and supervised learning methods for target audience classification on Twitter with minimal annotation efforts. Topic domains were automatically discovered from contents shared by followers of an account owner using Twitter Latent Dirichlet Allocation (LDA). A Support Vector Machine (SVM) ensemble was then trained using contents from different account owners of the various topic domains identified by Twitter LDA. Experimental results show that the methods presented are able to successfully identify a target audience with high accuracy. In addition, we show that using a statistical inference approach such as bootstrapping in over-sampling, instead of using random sampling, to construct training datasets can achieve a better classifier in an SVM ensemble. We conclude that such an ensemble system can take advantage of data diversity, which enables real-world applications for differentiating prospective customers from the general audience, leading to business advantage in the crowded social media space

Ranking of high-value social audiences on Twitter

Even though social media offers plenty of business opportunities, for a company to identify the right audience from the massive amount of social media data is highly challenging given finite resources and marketing budgets. In this paper, we present a ranking mechanism that is capable of identifying the top-k social audience members on Twitter based on an index. Data from three different Twitter business account owners were used in our experiments to validate this ranking mechanism. The results show that the index developed using a combination of semi-supervised and supervised learning methods is indeed generic enough to retrieve relevant audience members from the three different data sets. This approach of combining Fuzzy Match, Twitter Latent Dirichlet Allocation and Support Vector Machine Ensemble is able to leverage on the content of account owners to construct seed words and training data sets with minimal annotation efforts. We conclude that this ranking mechanism has the potential to be adopted in real-world applications for differentiating prospective customers from the general audience and enabling market segmentation for better business decision making

Identifying the high-value social audience from Twitter through text-mining methods

Doing business on social media has become a common practice for many companies these days. While the contents shared on Twitter and Facebook offer plenty of opportunities to uncover business insights, it remains a challenge to sift through the huge amount of social media data and identify the potential social audience who is highly likely to be interested in a particular company. In this paper, we analyze the Twitter content of an account owner and its list of followers through various text mining methods, which include fuzzy keyword matching, statistical topic modeling and machine learning approaches. We use tweets of the account owner to segment the followers and identify a group of high-value social audience members. This enables the account owner to spend resources more effectively by sending offers to the right audience and hence maximize marketing efficiency and improve the return of investment

Is a Pretrained Model the Answer to Situational Awareness Detection on Social Media?

Social media can be valuable for extracting information about an event or incident on the ground. However, the vast amount of content shared, and the linguistic variants of languages used on social media make it challenging to identify important situational awareness content to aid in decision-making for first responders. In this study, we assess whether pretrained models can be used to address the aforementioned challenges on social media. Various pretrained models, including static word embedding (such as Word2Vec and GloVe) and contextualized word embedding (such as DistilBERT) are studied in detail. According to our findings, a vanilla DistilBERT pretrained language model is insufficient to identify situation awareness information. Fine-tuning by using datasets of various event types and vocabulary extension is essential to adapt a DistilBERT model for real-world situational awareness detection

Transformer-Based Multi-Task Learning for Crisis Actionability Extraction

Social media has become a valuable information source for crisis informatics. While various methods were proposed to extract relevant information during a crisis, their adoption by field practitioners remains low. In recent fieldwork, actionable information was identified as the primary information need for crisis responders and a key component in bridging the significant gap in existing crisis management tools. In this paper, we proposed a Crisis Actionability Extraction System for filtering, classification, phrase extraction, severity estimation, localization, and aggregation of actionable information altogether. We examined the effectiveness of transformer-based LSTM-CRF architecture in Twitter-related sequence tagging tasks and simultaneously extracted actionable information such as situational details and crisis impact via Multi-Task Learning. We demonstrated the system’s practical value in a case study of a real-world crisis and showed its effectiveness in aiding crisis responders with making well-informed decisions, mitigating risks, and navigating the complexities of the crisis

Do Sequels Outperform or Disappoint? Insights from an Analysis of Amazon Echo Consumer Reviews

Rapid technological advances in recent years drastically transformed our world. Amidst modern technological inventions such as smart phones, smart watches and smart home devices, consumers of electronic digital devices experience greatly improved automation, productivity, and efficiency in conducting routine daily tasks, information searching, shopping as well as finding entertainment. In the last few years, the global smart speaker market has undergone significant growth. As technology continues to advance and smart speakers are equipped with innovative features, the adoption of smart speakers will increase and so will consumer expectations. This research paper presents an aspect-specific sentiment analysis of consumer reviews of the first three generations of Amazon Echo. Our text mining and aspect-specific sentiment analyses reveal that price, sound, smart home, connectivity, and comparison are outperforming aspects whereas voice, app, Q&A, companionship, and shelf life are disappointing and sunsetting aspects. Our study demonstrates a novel cross-generation visualization of directional changes in consumer sentiment using the Bollinger Bands and volume charts

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication